Volume 11 - Number 2

April - June 2009

Neuropsychiatric Symptoms Associated with Efavirenz: Prevalence, Correlates and Management. A Neurobehavioral Review

José A. Muñoz-Moreno, Carmina R. Fumaz, Maria J. Ferrer, Marian González-García, José Moltó, Eugènia Negredo and Bonaventura Clotet   |Full Article in PDF|

Lluita Contra la SIDA Foundation. Germans Trias i Pujol University Hospital. Badalona, Barcelona, Spain


The non-nucleoside analog reverse transcriptase inhibitor efavirenz is one of the most common components of HAART. Neuropsychiatric symptoms are frequently reported in patients taking efavirenzbased regimens. These symptoms are usually transient, although they can sometimes persist for up to two years after initiation of treatment. This review describes in detail the most common neuropsychiatric symptoms related to efavirenz, outlines relevant and recent findings on this agent, and suggests possible interventions based on neurobehavioral results. Different recommendations on the assessment of efavirenz-related adverse events are also provided.

Key Words:

Efavirenz. Antiretroviral therapy. HIV infection.

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