Volume 14 - Number 1

January - March 2011



Renal Complications in HIV Disease: Between Present and Future


Paolo Maggi, Dario Bartolozzi, Paolo Bonfanti, Leonardo Calza, Chiara Cherubini, Antonio Di Biagio, Simone Marcotullio, Francesco Montella, Vincenzo Montinaro, Cristina Mussini, Pasquale Narciso, Stefano Rusconi and Fabio Vescini |Full Article in PDF|

Clinic of Infectious Disease, University Hospital, Bari, Italy


Abstract

The recent introduction of new antiretroviral drugs, characterized by high efficiency and improved safety profiles, has not reduced the incidence of long-term adverse effects, in some cases manifested as selective organ damage. The presence of organ damage in patients receiving antiretroviral treatment is not only the expression of treatment toxicity, but also a complex interaction between individual risk factors, HIV-correlated effects, and antiretroviral drug toxicity. Kidney damage belongs to these adverse events. Renal function abnormalities are present in a large percentage of patients with HIV infection. Moreover, HIV-associated renal disease seems to be associated with progression to AIDS and death. In this review we address the various aspects of the epidemiology of renal damage, the interaction and the convergent effect of HIV and antiretroviral drugs in the onset of kidney injury, the interplay between kidney function and other organ systems, early clinical management, the monitoring of renal function, and a proposal of clinical approach to kidney disease in daily practice. Finally, we discuss future perspectives of renal damage in HIV patients and evaluate the patient’s perspective.


Key Words:

HIV. Kidney. Antiretroviral therapy. Tenofovir. Renal disease.






Contact Us

Permanyer Publications

  • Mallorca, 310 Barcelona, Spain.  08037
Phone / Fax
  • +34 93 207 59 20
  • +34 93 457 66 42
Email
  • permanyer@permanyer.com

     © 2017 Permanyer Publications  -  Legal Notice - Cookies Policy  -  ISSN 1698-6996