Volume 15 - Number 1

January - March 2013

The Changing Epidemiology of Liver Disease in HIV Patients

Vincent Soriano, Pablo Barreiro and Kenneth E. Sherman   |Full Article in PDF|

Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain


Liver disease continues to be one of the leading causes of hospitalization and death in HIV-infected individuals. Important etiologies include both alcoholic and non-alcoholic steatohepatitis, and coinfection with hepatitis viruses B and C. While non-alcoholic fatty liver disease is increasingly diagnosed in this population, most cases of chronic hepatitis B can be well controlled with tenofovir-based regimens, and hepatitis C has entered a revolutionary era in which most patients may be cured with direct-acting antivirals. However, important gaps remain unaddressed. Hepatitis delta is a neglected disease, despite 15 million people being infected worldwide, and represents the most severe form of viral hepatitis. Hepatitis E is largely unrecognized, despite being the major cause of acute viral hepatitis worldwide and occasionally leading to chronicity in immunosuppressed individuals.

Key Words:

Hepatitis C. HIV. Hepatitis B. Hepatitis delta. Hepatitis E. Antiviral therapy.

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