Volume 19 - Number 1

January - March 2017



Hot News

Similar Immunological Profiles Between Nonprogressing HIV Infection in Children and Nonpathogenic SIV Infection


Eva Poveda and Enrique Martin-Gayo   |Full Article in PDF|

Division of Clinical Virology, INIBIC-Complejo Hospitalario Universitario A Coruña, Spain


Abstract

In the absence of antirretroviral therapy (ART), HIV infection leads to progression to AIDS in most infected individuals. However, there is a small group of HIV-infected patients capable of spontaneously controlling HIV infection, known as the elite controllers (less than 1% of total infected population). These patients maintain undetectable levels of HIV replication, in part, due to a continuously effective HIV specific T cell response. Moreover, in HIV-infected patients with suppressed viremia under ART, a chronic activation of the immune system persist, which can be related to a poor clinical outcome including death, development of co-morbidities, AIDS and non-AIDS defining events. Indeed, several studies highlight that a high level of immune activation rather than HIV replication is the major contributing factor to progression during HIV infection.


Key Words:






Contact Us

Permanyer Publications

  • Mallorca, 310 Barcelona, Spain.  08037
Phone / Fax
  • +34 93 207 59 20
  • +34 93 457 66 42
Email
  • permanyer@permanyer.com




     © 2017 Permanyer Publications  -  Legal Notice - Cookies Policy  -  ISSN 1698-6996